Lee Lab

X-chromosome inactivation: w​here RNA meets epigenetics & the 3D genome.

We use X-inactivation as a model to study basic questions in genome biology. Using an interdisciplinary approach, we address how non-coding RNAs direct changes in 3D genome organization. RNA has a special place in epigenetics by being uniquely capable of site-specific action. Our recent discovery that “junk RNA” such as B2 SINEs can function as epigenetic ribozymes puts a new spin on RNA Biology.